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Curr Genet. 2016 Feb;62(1):25-9. doi: 10.1007/s00294-015-0505-y. Epub 2015 Jul 12.

Negative epistasis: a route to intraspecific reproductive isolation in yeast?

Author information

1
Department of Genetics, Genomics and Microbiology, University of Strasbourg / CNRS, UMR7156, Strasbourg, France.
2
Department of Genetics, Genomics and Microbiology, University of Strasbourg / CNRS, UMR7156, Strasbourg, France. schacherer@unistra.fr.

Abstract

Exploring the molecular bases of intraspecific reproductive isolation captures the ongoing phenotypic consequences of genetic divergence and provides insights into the early onset of speciation. Recent species-wide surveys using natural populations of yeasts demonstrated that intrinsic post-zygotic reproductive isolation segregates readily within the same species, and revealed the multiplicity of the genetic mechanisms underlying such processes. These advances deepened our current understandings and opened further perspectives regarding the complete picture of molecular and evolutionary origins driving the onset of intraspecific reproductive isolation in yeasts.

KEYWORDS:

Epistatic interaction; Genetic incompatibility; Intraspecific diversity; Reproductive isolation; Saccharomyces cerevisiae; Yeast

PMID:
26164016
PMCID:
PMC4710551
DOI:
10.1007/s00294-015-0505-y
[Indexed for MEDLINE]
Free PMC Article

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