Format

Send to

Choose Destination
Vaccine. 2015 Aug 26;33(36):4422-9. doi: 10.1016/j.vaccine.2015.06.101. Epub 2015 Jul 8.

The weight of obesity on the human immune response to vaccination.

Author information

1
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
2
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA; Division of General Internal Medicine, USA. Electronic address: poland.gregory@mayo.edu.

Abstract

Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI) ≥ 30 kg/m(2). The immune system is adversely affected by obesity, and these "immune consequences" raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.

KEYWORDS:

Communicable diseases; Immunity; Immunization; Obesity; Vaccination

PMID:
26163925
PMCID:
PMC4547886
DOI:
10.1016/j.vaccine.2015.06.101
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center