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J Cardiol. 2016 Apr;67(4):347-51. doi: 10.1016/j.jjcc.2015.06.002. Epub 2015 Jul 7.

The association of circulating inflammatory and oxidative stress biomarker levels with diagonal earlobe crease in patients with atherosclerotic diseases.

Author information

1
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
2
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan. Electronic address: hirow@doc.med.akita-u.ac.jp.

Abstract

BACKGROUND:

Earlobe creases (ELC) are frequently observed in patients with atherosclerosis. Atherosclerosis is considered to be a systemic vascular inflammatory disease, and oxidative stress is known to be a contributor to vascular inflammation. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes. This study was designed to test the hypothesis that biomarkers of inflammation and oxidative stress are increased in patients with ELC.

METHODS:

A total of 223 consecutive patients with atherosclerotic risk factors were enrolled and divided into two groups. One group consisted of patients with ELC (ELC group, n=134) and the other was without ELC (non-ELC group, n=89). Medical information and biomarker levels related to atherosclerosis were acquired from these patients.

RESULTS:

The male ratio, prevalence of hypertension, diabetes mellitus, and MDA-LDL, hs-CRP, and PTX3 levels were found to be higher in the ELC group, compared with the non-ELC group. A multiple logistic regression analysis showed that PTX3 levels, rather than hs-CRP, constituted the strongest predictive factor for the appearance of ELC.

CONCLUSIONS:

Vascular inflammation and oxidative stress are associated with the presence of ELC.

KEYWORDS:

Earlobe crease; High-sensitivity C-reactive protein; Inflammatory response; Malondialdehyde low-density lipoprotein; Oxidative stress; Pentraxin3

PMID:
26162942
DOI:
10.1016/j.jjcc.2015.06.002
[Indexed for MEDLINE]
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