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ACS Appl Mater Interfaces. 2015 Aug 5;7(30):16257-65. doi: 10.1021/acsami.5b05194. Epub 2015 Jul 27.

NaGdF4:Yb(3+)/Er(3+)@NaGdF4:Nd(3+)@Sodium-Gluconate: Multifunctional and Biocompatible Ultrasmall Core-Shell Nanohybrids for UCL/MR/CT Multimodal Imaging.

Author information

1
†Department of Applied Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, China.
2
‡Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi'an Jiaotong University, Xi'an 710061, China.
3
§Department of Diagnostic Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Abstract

Multimodal bioimaging nanoparticles by integrating diverse imaging ingredients into one system, represent a class of emerging advanced materials that provide more comprehensive and accurate clinical diagnostics than conventional contrast agents. Here monodisperse and biocompatible core-shell nanoparticles, NaGdF4: Yb(3+)/Er(3+)@NaGdF4:Nd@sodium-gluconate (termed as GNa-Er@Nd), with about 26 nm in diameter were successfully prepared by a facile two step reactions in high boiling solvents, and followed a ligand exchange process with sodium gluconate. The resulting GNa-Er@Nd nanoparticles were well characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), and zeta potentials. These nanohybrids present brightly dual-wavelength excited upconversion luminescence (UCL) under both 980 and 793 nm laser because of the synergistic effect of Yb(3+)/Er(3+) and Nd(3+). They also exhibited excellent relaxivity parameters (r1) in magnetic resonance imaging (MRI) and Hounsfield units (HU) in X-ray computed tomography (CT) that are comparable to the clinical contrast agents. Therefore, these small and monodisperse nanoparticles provide options to construct a unique platform for potential multimodal UCL/CT/MRI imaging simultaneously.

KEYWORDS:

biocompatibility; core−shell; multimodal imaging; sodium-gluconate; upconversion nanoparticles

PMID:
26161913
DOI:
10.1021/acsami.5b05194
[Indexed for MEDLINE]

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