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PLoS One. 2015 Jul 10;10(7):e0132472. doi: 10.1371/journal.pone.0132472. eCollection 2015.

Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.

Author information

1
Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Wakamatsu-cho 2-2, Shinjuku-ku, Tokyo, Japan.
2
Central Research Laboratory, Nippon Suisan Kaisha Ltd., Nanakuni 1-32-3, Hachioji, Tokyo, Japan.
3
Department of Genomic Drug Discovery Sciences, Kyoto University, 46-29, Yoshida, Sakyo-ku, Kyoto, Japan; Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Kawada-cho 8-1, Shinjuku-ku, Tokyo, Japan.

Abstract

The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.

PMID:
26161796
PMCID:
PMC4498928
DOI:
10.1371/journal.pone.0132472
[Indexed for MEDLINE]
Free PMC Article

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