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Clin Biochem. 2015 Dec;48(18):1277-82. doi: 10.1016/j.clinbiochem.2015.07.003. Epub 2015 Jul 6.

SLC6A14 and 5-HTR2C polymorphisms are associated with food intake and nutritional status in children.

Author information

1
Laboratório de Biologia Molecular, Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245/Anexo 2 - sala 07, CEP 90050-170, Porto Alegre, RS, Brazil.
2
Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245 - sala 309, CEP 90050-170, Porto Alegre, RS, Brazil.
3
Núcleo de Pesquisa em Nutrição (NUPEN), Departamento de Nutrição, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245/Anexo 2 - sala 03, CEP 90050-170, Porto Alegre, RS, Brazil.
4
Laboratório de Biologia Molecular, Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245/Anexo 2 - sala 07, CEP 90050-170, Porto Alegre, RS, Brazil; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245 - sala 309, CEP 90050-170, Porto Alegre, RS, Brazil.
5
Laboratório de Biologia Molecular, Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245/Anexo 2 - sala 07, CEP 90050-170, Porto Alegre, RS, Brazil; Departamento de Ciências Básicas da Saúde, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Sarmento Leite, 245 - sala 309, CEP 90050-170, Porto Alegre, RS, Brazil. Electronic address: silvana.almeida@pq.cnpq.br.

Abstract

BACKGROUND:

Serotonin plays a critical role in the regulation of food intake. The solute carrier family 6 member 14 (SLC6A14) and serotonin receptor 2C (5-HTR2C) genes are involved in the bioavailability and action of this neurotransmitter.

OBJECTIVE:

Evaluation of the association of six polymorphisms in these genes with food intake and nutritional status in children followed to 7-8years of age.

DESIGN:

Blood samples and the biodemographic data of 344 children were collected at three development stages, in a cross-sectional study undertaken with the cohort from a randomized trial. Polymorphisms were analyzed using polymerase chain reaction-based techniques.

RESULTS:

At 7 to 8years of age, carriers of the A alleles for both the SLC6A14 rs2312054 and SLC6A14 rs12391221 polymorphisms showed higher food intake, except for the sugar-dense food (SDF) intake parameter, than T/T and C/C homozygotes, respectively. Boy carriers of the C allele of rs2071877 had a higher sum of triceps and subscapular folds than T allele carriers at 7 to 8years old. For 5-HTR2C gene variants, A allele carriers (rs3813928) and T allele carriers (rs3813929) had higher food intake at 3 to 4years old than G/G and C/C homozygotes, respectively, except for SDF. At this age, the intake of energy-dense foods was higher in carriers of the T allele (rs3813929) than in C/C homozygotes.

CONCLUSION:

This study provides evidence that genetic variants of these proteins might be involved in the determination of food intake and nutritional status in children.

KEYWORDS:

Children; Eating; Genetic polymorphism; Obesity; Serotonin

[Indexed for MEDLINE]

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