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Cell Host Microbe. 2015 Jul 8;18(1):1-2. doi: 10.1016/j.chom.2015.06.013.

Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.

Author information

1
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA.
2
Department of MCDB, University of Michigan, Ann Arbor, MI 48109-1048, USA.
3
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: hultgren@wusm.wustl.edu.

Abstract

Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.

PMID:
26159711
PMCID:
PMC5290729
DOI:
10.1016/j.chom.2015.06.013
[Indexed for MEDLINE]
Free PMC Article

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