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Exp Gerontol. 2015 Sep;69:189-95. doi: 10.1016/j.exger.2015.06.021. Epub 2015 Jul 6.

Cranberry anthocyanin extract prolongs lifespan of fruit flies.

Author information

1
Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
2
Food and Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. Electronic address: zhenyuchen@cuhk.edu.hk.

Abstract

Cranberry is an excellent source of dietary antioxidants. The present study investigated the effect of cranberry anthocyanin (CrA) extract on the lifespan of fruit flies with focus on its interaction with aging-related genes including superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), insulin receptor (InR), target of rapamycin (TOR), hemipterus (Hep), and phosphoenolpyruvate carboxykinase (PEPCK). Results showed that diet containing 20mg/mL CrA could significantly prolong the mean lifespan of fruit flies by 10% compared with the control diet. This was accompanied by up-regulation of SOD1 and down-regulation of MTH, InR, TOR and PEPCK. The stress resistance test demonstrated that CrA could reduce the mortality rate induced by H2O2 but not by paraquat. It was therefore concluded that the lifespan-prolonging activity of CrA was most likely mediated by modulating the genes of SOD1, MTH, InR, TOR and PEPCK.

KEYWORDS:

Anthocyanins; Antioxidants; Cranberry; Insulin receptor; Target of rapamycin

PMID:
26159161
DOI:
10.1016/j.exger.2015.06.021
[Indexed for MEDLINE]

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