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Nat Rev Cancer. 2015 Aug;15(8):473-83. doi: 10.1038/nrc3971. Epub 2015 Jul 2.

Tumorigenesis: it takes a village.

Author information

1
1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] BBS Program, Harvard Medical School, Boston, Massachusetts 02115, USA.
2
1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA. [2] BBS Program, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA. [4] Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Although it is widely accepted that most cancers exhibit some degree of intratumour heterogeneity, we are far from understanding the dynamics that operate among subpopulations within tumours. There is growing evidence that cancer cells behave as communities, and increasing attention is now being directed towards the cooperative behaviour of subclones that can influence disease progression. As expected, these interactions can add a greater layer of complexity to therapeutic interventions in heterogeneous tumours, often leading to a poor prognosis. In this Review, we highlight studies that demonstrate such interactions in cancer and postulate ways to overcome them with better-designed therapeutic strategies.

PMID:
26156638
DOI:
10.1038/nrc3971
[Indexed for MEDLINE]

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