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J Am Coll Nutr. 2016 May-Jun;35(4):346-53. doi: 10.1080/07315724.2015.1021057. Epub 2015 Jul 9.

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

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a Department of Nutrition, Nutrition and Metabolic Disease Research Center, Faculty of Paramedicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
b Department of Institute for Infectious Diseases of the Digestive System, Faculty of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
c Department of Radiology, Faculty of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
d Department of Statistics, Faculty of Public Health , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , IRAN.
e Department of Food Hygiene, Faculty of Veterinary Medicine , Shahid Chamran University of Ahvaz , Ahvaz , IRAN.



Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder related to inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been considered as an anti-inflammatory factor. In the current study we aimed to evaluate the effects of CoQ10 supplementation on liver enzymes, inflammation status, and adipokines in patients with NAFLD.


Forty-one subjects with NAFLD participated in the current randomized, double-blind, placebo-controlled trial. The participants were randomly divided into 2 groups: one group received CoQ10 capsules (100 mg once a day) and the other received placebo for 12 weeks. Blood samples of each patient were taken before and after the 12-week intervention period for measurement of liver aminotransferases, inflammatory biomarkers, and adipokines (adiponectin and leptin).


Taking 100 mg CoQ10 supplement daily resulted in a significant decrease in liver aminotransferases (aspartate aminotransferase [AST] and gamma-glutamyl transpeptidase [GGT]), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor α, and the grades of NAFLD in the CoQ10 group in comparison to the control group (p < 0.05). In addition, patients who received CoQ10 supplement had higher serum levels of adiponectin (p = 0.016) and considerable changes in serum leptin (p = 0.053). However, no significant changes occurred in serum levels of interleukin-6 in both groups.


The present study suggested that CoQ10 supplement at a dosage of 100 mg could be effective for improving the systemic inflammation and biochemical variables in NAFLD.


adipocytokines; coenzyme Q10 (CoQ10); inflammation; nonalcoholic fatty liver disease (NAFLD)

[Indexed for MEDLINE]

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