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Life Sci. 1989;45(26):2587-90.

Temporal variations in the erythrocyte permeability to bupivacaine, etidocaine and mepivacaine in mice.

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1
Laboratoire de Pharmacologie Médicale, Faculté de Médecine de Marseille.

Abstract

Temporal changes in membrane permeability to bupivacaine (B), etidocaine (E) and mepivacaine (M) documented by their erythrocytic penetration were studied in mice. Temporal variations of B, E and M erythrocytic penetration were demonstrated with a maximum at 04.00 h for B (amplitude = 148%), 10.00 h for E (amplitude = 146%) and at 10.00 h for M (amplitude = 75%). Differences in the circadian pattern of erythrocytic penetration of B, E and M are discussed according to physicochemical properties of these three agents.

PMID:
2615557
[Indexed for MEDLINE]
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