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Infect Dis Clin North Am. 2015 Sep;29(3):391-400. doi: 10.1016/j.idc.2015.05.001. Epub 2015 Jul 4.

Neonatal Herpes Simplex Virus Infection.

Author information

1
Department of Pediatrics, University of Alabama at Birmingham, Children's Harbor Building 308, 1600 7th Avenue South, Birmingham, AL 35233-1711, USA.
2
Department of Pediatrics, University of Alabama at Birmingham, Children's Harbor Building 303, 1600 7th Avenue South, Birmingham, AL 35233-1711, USA. Electronic address: dkimberlin@peds.uab.edu.

Abstract

Herpes simplex virus (HSV) 1 and HSV-2 infections are highly prevalent worldwide and are characterized by establishing lifelong infection with periods of latency interspersed with periodic episodes of reactivation. Acquisition of HSV by an infant during the peripartum or postpartum period results in neonatal HSV disease, a rare but significant infection that can be associated with severe morbidity and mortality, especially if there is dissemination or central nervous system involvement. Diagnostic and therapeutic advances have led to improvements in mortality and, to a lesser extent, neurodevelopmental outcomes, but room exists for further improvement.

KEYWORDS:

Antiviral therapy; Genital herpes; Herpes simplex virus; Mother-to-child transmission; Neonatal herpes

PMID:
26154662
DOI:
10.1016/j.idc.2015.05.001
[Indexed for MEDLINE]

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