Format

Send to

Choose Destination
Int J Environ Res Public Health. 2015 Jul 6;12(7):7519-40. doi: 10.3390/ijerph120707519.

Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.

Author information

1
Neuroscience Department, Oberlin College, Oberlin, OH 44074, USA. gkwakye@oberlin.edu.
2
Graduate Program in Public Health, Department of Pathology, Clinical and Toxicological Analysis, Center of Health Science, State University of Londrina, Parana 10011, Brazil. monibas2@gmail.com.
3
Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Cellular & Molecular Biology, and Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, USA. som@austin.utexas.edu.
4
Department of Neurology and Pediatrics, Vanderbilt University, Nashville, TN 37240, USA. aaron.bowman@vanderbilt.edu.
5
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Michael.Aschner@einstein.yu.edu.

Abstract

Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson's disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson's disease (PD).

KEYWORDS:

Parkinson’s disease (PD); manganese neurotoxicity; manganese-induced parkinsonism; manganism; neurodegenerative diseases

PMID:
26154659
PMCID:
PMC4515672
DOI:
10.3390/ijerph120707519
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center