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Sci Rep. 2015 Jul 8;5:12012. doi: 10.1038/srep12012.

Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin.

Author information

1
MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China.
2
1] MOE Key Laboratory of Protein Sciences, School of Medicine, Tsinghua University, Beijing 100084, P.R. China [2] Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo 226-8051, Japan.
3
Department of chemistry, Tsinghua University, Beijing 100084, P.R. China.

Abstract

Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction. Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity. These findings suggest that cAMP slows the ageing process and is a good candidate to mimic calorie restriction. Our research provides a promising therapeutic strategy to target metabolic disorder-induced ageing-related diseases.

PMID:
26153625
PMCID:
PMC4648391
DOI:
10.1038/srep12012
[Indexed for MEDLINE]
Free PMC Article

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