Format

Send to

Choose Destination
Nephrol Dial Transplant. 2016 Apr;31(4):602-8. doi: 10.1093/ndt/gfv229. Epub 2015 Jul 6.

APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.

Author information

1
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
2
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
3
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
4
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
5
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
6
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
7
Department of Internal Medicine-Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Abstract

BACKGROUND:

Two independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial. Although APOL1 binds plasma high-density lipoproteins (HDLs), data on APOL1 risk variant associations with HDL subfractions are sparse.

METHODS:

Two APOL1 G1 single nucleotide polymorphisms and the G2 insertion/deletion polymorphism were genotyped in 2010 Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study participants with nuclear magnetic resonance spectroscopy-based lipoprotein subfraction measurements. Linear regression was used to model associations between numbers of APOL1 G1/G2 risk variants and HDL subfractions, adjusting for demographic, clinical and ancestral covariates.

RESULTS:

Female sex and higher percentage of African ancestry were positively associated with the number of APOL1 G1/G2 risk alleles. In the unadjusted analysis, mean (standard error) small HDL concentrations (μmol/L) for participants with zero, one and two G1/G2 risk alleles were 19.0 (0.2), 19.7 (0.2) and 19.9 (0.4), respectively (P = 0.02). Adjustment for age, sex, diabetes and African ancestry did not change the results but strengthened the statistical significance (P = 0.004). No significant differences in large or medium HDL, very low-density lipoprotein or low-density lipoprotein particle concentrations were observed by APOL1 genotype.

CONCLUSIONS:

Greater numbers of APOL1 G1/G2 risk alleles were associated with higher small HDL particle concentrations in African Americans. These results may suggest novel areas of investigation to uncover reasons for the association between APOL1 risk variants with adverse outcomes in African Americans.

KEYWORDS:

APOL1; chronic kidney disease; ethnic disparities; genetics

PMID:
26152403
PMCID:
PMC4805128
DOI:
10.1093/ndt/gfv229
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center