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Med Sci (Paris). 2015 Jun-Jul;31(6-7):622-8. doi: 10.1051/medsci/20153106015. Epub 2015 Jul 7.

[About the ribosomal biogenesis in human].

[Article in French]

Author information

1
Laboratoire de biologie cellulaire, institut de recherche en biosciences, université de Mons, place du Parc 20, 7000 Mons, Belgique.

Abstract

Ribosomes are cellular ribonucleoprotein particles required for a fundamental mechanism, translation of the genetic information into proteins. Ribosome biogenesis is a highly complex pathway involving many maturation steps: ribosomal RNA (rRNA) synthesis, rRNA processing, pre-rRNA modifications, its assembly with ribosomal proteins in the nuceolus, export of the subunit precursors to the nucleoplasm and the cytoplasm. Ribosome biogenesis has mainly being investigated in yeast during these last 25 years. However, recent works have shown that, despite many similarities between yeast and human ribosome structure and biogenesis, human pre-rRNA processing is far more complex than in yeast. In order to better understand diseases related to a malfunction in ribosome synthesis, the ribosomopathies, research should be conducted directly in human cells and animal models.

PMID:
26152166
DOI:
10.1051/medsci/20153106015
[Indexed for MEDLINE]
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