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Food Chem Toxicol. 2015 Sep;83:237-50. doi: 10.1016/j.fct.2015.06.025. Epub 2015 Jul 4.

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens--In vitro study mimicking real-life consumer habits.

Author information

1
Laboratories of Cosmetology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. Electronic address: zuzana.klimova@stuba.sk.
2
Laboratories of Cosmetology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. Electronic address: jarmila.hojerova@stuba.sk.
3
Laboratories of Cosmetology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic. Electronic address: martina.berankova@stuba.sk.

Abstract

Due to health concerns about safety, three UV-filters (Benzophenone-3, BP3, 10%; Ethylhexyl Methoxycinnamate, EHMC, 10%; Butyl Methoxydibenzoylmethane, BMDBM; 5%) were examined in vitro for absorption on full-thickness pig-ear skin, mimicking human in-use conditions. Kinetic profiles confirmed the rapid permeation of BP3; after the first hour of skin (frozen-stored) exposure to 2 mg/cm(2) (W/O sunscreen; recommended but unrealistic amount), about 0.5% of the applied dose passed into the receptor fluid. The absorption rate of filters was higher from W/O than from O/W emulsions. The fresh/frozen-stored skin permeability coefficient (0.83-0.54) for each UV filter was taken into account. Systemic Exposure Dosage of BP3, EHMC, BMDBM for humans as a consequence of (i) whole-body and (ii) face treatment with 0.5 mg/cm(2) of W/O sunscreen for 6-h skin exposure followed by washing and subsequent 18-h permeation (a realistic scenario) were estimated to be (i) 4744, 1032 and 1036 μg/kg-bw/day, and (ii) 153, 33 and 34 μg/kg-bw/day, respectively. From Margin of Safety for BP3, EHMC and BMDBM (i) 42, 485 and 192 as well as (ii) 1307; 15,151 and 5882, respectively, only the value of 42 (<100) for BP3 indicated a possible health risk. Escalation of a phobia towards all organic UV filters is undesirable.

KEYWORDS:

Benzophenone; Butyl Methoxydibenzoylmethane; Dermal permeation; Ethylhexyl Methoxycinnamate; Margin of Safety; Systemic Exposure Dosage

PMID:
26151237
DOI:
10.1016/j.fct.2015.06.025
[Indexed for MEDLINE]

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