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J Thromb Haemost. 2015 Jun;13 Suppl 1:S55-62. doi: 10.1111/jth.12942.

Road blocks in making platelets for transfusion.

Author information

1
Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
2
Harvard Medical School, Boston, MA, USA.
3
Platelet BioGenesis, Chestnut Hill, MA, USA.

Abstract

The production of laboratory-generated human platelets is necessary to meet present and future transfusion needs. This manuscript will identify and define the major roadblocks that must be overcome to make human platelet production possible for clinical use, and propose solutions necessary to accelerate development of laboratory-generated human platelets to market.

KEYWORDS:

biomedical engineering; bioreactors; hematopoietic stem cells; megakaryocytes; platelets

PMID:
26149051
PMCID:
PMC5565795
DOI:
10.1111/jth.12942
[Indexed for MEDLINE]
Free PMC Article

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