Send to

Choose Destination
J Neurol Sci. 2015 Sep 15;356(1-2):163-7. doi: 10.1016/j.jns.2015.06.043. Epub 2015 Jun 24.

Inverse association between yerba mate consumption and idiopathic Parkinson's disease. A case-control study.

Author information

Instituto de Neurociencias Buenos Aires, INEBA, Buenos Aires, Argentina. Electronic address:
Fundación para la Investigación en Neuroepidemiología (FINEP), Junín, Provincia de Buenos Aires, Argentina.
Departamento Neurología, Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina.
Hospital A. Zubizarreta, Laboratorio de Investigación de la Memoria, Buenos Aires, Argentina.
Departamento de Farmacología, Facultad de Medicina, UBA, Argentina.


Yerba mate tea is a very common beverage in some countries of South America. We conducted a case-control study on an individual basis using hospital records to investigate the association between Parkinson's disease (PD) and yerba mate intake. A case was defined as an age of ≥ 40 years with ≥ 1 year of PD. Each case was individually matched by two controls. Exposure was measured by yerba mate consumption, coffee, tea, and alcohol intake and smoking status. The sample consisted of 223 PD patients (mean age 68 years and mean disease duration 7.3 years) and 406 controls. There was an inverse association between yerba mate "bombilla" consumption and PD (OR 0.64, 95% CI: 0.54-0.76, p=0.00001). A multivariate analysis with a logistic regression adjusted by sex, alcohol intake and smoking provided the following results: yerba mate (OR 0.63, 95% CI: 0.53-0.76), tea (OR 0.60, 95% CI: 0.42-0.86), coffee (OR 0.51, 95% CI: 0.35-0.73). We found an inverse association between yerba mate consumption and PD. These results led us to hypothesize that yerba mate may have a potential protective role in the development of PD.


Parkinson's disease; Risk factors; Yerba mate

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center