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Arch Oral Biol. 2015 Sep;60(9):1375-86. doi: 10.1016/j.archoralbio.2015.06.012. Epub 2015 Jun 22.

Antioxidant profile, carbonyl and lipid oxidation markers in the parotid and submandibular glands of rats in different periods of streptozotocin induced diabetes.

Author information

1
Department of Conservative Dentistry, Medical University Bialystok, Sklodowskiej M.C. 24a Str., 15-274 Bialystok, Poland. Electronic address: jmatczuk@yahoo.com.
2
Institute of Health Care Higher Vocational School, Noniewicza 10 Str., 16-400 Suwalki, Poland.
3
Students' Scientific Group "Stomatological Biochemistry" at the Department of Conservative Dentistry, Medical University of Bialystok, Sklodowskiej M.C. 24a Str., 15-274 Bialystok, Poland.
4
Department of Psychiatry, Medical University Bialystok, Plac Brodowicza 1 Str., 16-010 Choroszcz, Poland.
5
Department of Conservative Dentistry, Medical University Bialystok, Sklodowskiej M.C. 24a Str., 15-274 Bialystok, Poland.
6
County Veterinary Inspection, Zwycięstwa 26B Str., 15-959 Bialystok, Poland.
7
Department of Experimental Pharmacology, Medical University Bialystok, Szpitalna 37 Str., 15-767 Bialystok, Poland.

Abstract

OBJECTIVE:

The aim of this study was to estimate the antioxidants barrier, and the oxidative stress in the salivary glands of rats in different periods of streptozotocin induced diabetes.

DESIGN:

Rats were divided in: 4 control (C2/4/10/14) and 4 experimental (DM2/4/10/14) groups. Salivary glands were removed 2/4/10/14 weeks after streptozotocin injection. Peroxidase (Px), uric acid (UA), total antioxidant status (TAS), superoxide dismutases (SODs), catalase (CAT), malonylodialdehyde (MDA), advanced glycation end products (AGE) concentrations were examined.

RESULTS:

TAS, Px were lower in the parotid diabetic glands throughout the whole experiment. TAS in the submandibular diabetic glands was lower in 2nd and 4th and higher in 14th week. Px in the submandibular diabetic glands was reduced in 4th and increased in 14th week. UA was lower in parotid, elevated in submandibular diabetic glands in 4th, 10th, 14th weeks. In the submandibular as compared to parotid glands an increase in TAS and UA was observed in 10th and 14th, Px in 14th week. In all periods, a significant increase in AGE was observed in both diabetic salivary glands. An increase in MDA was observed in the parotid diabetic glands in the 4th, 10th, 14th of the study. In the submandibular glands this increase was observed in the 2nd, 4th, 10th week, in the 14th week, the MDA level was significantly reduced in comparison to the control.

CONCLUSION:

The antioxidants of parotid glands are deficient throughout the whole experiment. In the last period submandibular glands copy with free radicals, becoming the main antioxidant's source.

KEYWORDS:

AGE; Antioxidants; Diabetes; MDA; Salivary glands

[Indexed for MEDLINE]

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