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J Infect Dis. 2016 Jan 15;213(2):233-42. doi: 10.1093/infdis/jiv369. Epub 2015 Jul 3.

Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study.

Author information

1
Department of Immunology.
2
Department of The Generation R Study Group, Erasmus MC, University Medical Center Department of Pediatrics, Erasmus MC-Sophia, Rotterdam.
3
Department of Epidemiology Department of The Generation R Study Group, Erasmus MC, University Medical Center Department of Pediatrics, Erasmus MC-Sophia, Rotterdam.
4
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands.
5
Department of Pediatrics, Erasmus MC-Sophia, Rotterdam.

Abstract

BACKGROUND:

Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) induce effector memory T-cell expansions, which are variable and potentially depend on the age at primary exposure and coinfections. We evaluated the T-cell compartment and herpesvirus infections in 6-year-old children.

METHODS:

T-cell subsets and immunoglobulin G seropositivity for CMV, EBV, herpes-simplex virus 1, and varicella-zoster virus were studied in 1079 6-year-old children. A random subgroup of 225 children was evaluated for CMV and EBV seropositivity before 2 years of age and for vaccination responses against measles and tetanus.

RESULTS:

CMV and EBV infections were associated with significant expansions of CD27(-) and CD27(+) effector memory T cells, respectively. These expansions were enhanced in CMV-EBV-coinfected children and were independent of varicella-zoster virus or herpes-simplex virus 1 coinfection. Naive and central memory T-cell numbers were not affected, nor were anti-tetanus and anti-measles immunoglobulin G levels. Children infected before 2 years of age showed smaller effector memory T-cell expansions than those infected between 2 and 6 years of age.

CONCLUSIONS:

CMV- and EBV-related T-cell expansions do not impair naive T-cell numbers or maintenance of protective responses against nonrelated pathogens. Duration of infection was not directly related to larger expansions of effector memory T cells in children, suggesting that other mechanisms affect these expansions at later age.

KEYWORDS:

Epstein-Barr virus (EBV); T-cell compartment; childhood adaptive immune system; cytomegalovirus (CMV); effector memory T-cell expansions; herpes-simplex virus 1 (HSV-1); persistent herpesvirus infection; varicella-zoster virus (VZV)

PMID:
26142434
DOI:
10.1093/infdis/jiv369
[Indexed for MEDLINE]

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