Format

Send to

Choose Destination
Acta Diabetol. 2016 Apr;53(2):317-22. doi: 10.1007/s00592-015-0776-2. Epub 2015 Jul 4.

Pharmacokinetics of the transdermal delivery of benfotiamine.

Author information

1
BioChemics Inc., 99 Rosewood Drive, Suite 270, Danvers, MA, 01923-4537, USA. pzhu@biochemics.com.
2
BioChemics Inc., 99 Rosewood Drive, Suite 270, Danvers, MA, 01923-4537, USA.
3
Intrepid Life Sciences, Andover, MA, 01810, USA.

Abstract

AIMS:

Accumulation of advanced glycation endpoints is a trigger to the development of diabetic peripheral neuropathy, which is a common complication of diabetes. Oral administration of benfotiamine (BFT) has shown some preclinical and clinical promise as a treatment for diabetic peripheral neuropathy. The purpose of this study was to evaluate the method of transdermal delivery of BFT as a possible, viable route of administration for the treatment of diabetic peripheral neuropathy.

METHODS:

A single application of 10 mg of BFT was given to guinea pigs topically. The levels of thiamine (T), thiamine monophosphate, thiamine diphosphate, S-benzoylthiamine and BFT were measured in the blood, skin and muscle at different time points within 24 h.

RESULTS:

At the 24-h time point, following the single BFT dose, the T level was increased 10× in the blood, more than 7× in the skin and almost 4× in the muscle compared to the untreated animals. The total T content (total) was increased 7× in the blood, 17× in the skin and 3× in the muscle compared to the untreated animals.

CONCLUSIONS:

This strong increase in the tissue levels of T and the associated metabolic derivatives levels found in the blood and local tissues following a single dose indicate that topically applied BFT may be a viable and advantageous delivery method for the treatment of diabetic peripheral neuropathy.

KEYWORDS:

Advanced glycation endproducts; Benfotiamine; Blood; Diabetic neuropathy; Muscle; Skin; Thiamine; Transdermal delivery

PMID:
26141141
DOI:
10.1007/s00592-015-0776-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center