Format

Send to

Choose Destination
Actas Dermosifiliogr. 2015 Oct;106(8):638-43. doi: 10.1016/j.ad.2015.04.013. Epub 2015 Jun 30.

Does the treatment ladder for systemic therapy in moderate to severe psoriasis only go up? The percentage of patients with severe psoriasis on biologics increases over time.

[Article in English, Spanish]

Author information

1
Hospital Universitari Germans Trías i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: jmcarrascosac@hotmail.com.
2
Hospital Universitari Germans Trías i Pujol, Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain.
3
Research Unit, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain.
4
Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain.
5
Hospital Universitario 12 de Octubre, Madrid, Spain.
6
Hospital Universitario la Princesa, Madrid, Spain.
7
Hospital Universitario Reina Sofía, Córdoba, Spain.
8
Hospital Infanta Leonor, Madrid, Spain.
9
Hospital Universitario Virgen de la Victoria, Málaga, Spain.
10
Hospital General Universitario de Alicante, Alicante, Spain.
11
Hospital Clínic de Barcelona, Barcelona, Spain.
12
Hospital General Universitario de Valencia, Valencia, Spain.
13
Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
14
Hospital Universitario Fundación de Alcorcón, Madrid, Spain.
15
Research Unit, Fundación Academia Española de Dermatología y Venereología, Madrid, Spain; Hospital Universitario de Albacete, Albacete, Spain.

Abstract

BACKGROUND:

With the advent of biologic drugs in the management of moderate to severe psoriasis, there may have been a shift in therapeutic approach from rotational strategies to a unidirectional progression from topical treatments to the highest rung of the therapeutic ladder. We studied the frequency of switching from classic to biologic therapy and vice versa in a cohort of patients with psoriasis over a period of up to 5 years.

METHODS:

Patients are included in the BIOBADADERM prospective registry when they are first prescribed any specific conventional or biologic systemic treatment. The data for each patient refer to the follow-up period from the time they entered the cohort until October 2013. To describe the pattern of switches from classic to biologic therapy and vice versa, we used the data in the registry on the first day of every 365-day period following the date each patient was included in the cohort.

RESULTS:

In total, 47.3% of the patients (926/1956) were prescribed a classic systemic drug and 52.7% (1030/1956) a biologic agent on entry into the study. Of the 741 patients who accumulated 5 years of follow-up, 21.9% (155) were receiving nonbiologic drugs and 78.1% (553) were on biologic therapy on the first day of their 5th year of follow-up.

CONCLUSIONS:

The proportion of patients receiving biologic therapy increased with longer follow-up.

KEYWORDS:

Biologic; Biológico; Convencional; Conventional; Psoriasis; Sistémico; Systemic; Therapy; Tratamiento

PMID:
26141003
DOI:
10.1016/j.ad.2015.04.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ediciones Doyma, S.L.
Loading ...
Support Center