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Cell Stem Cell. 2015 Jul 2;17(1):1-3. doi: 10.1016/j.stem.2015.06.011.

Direct Reprogramming of RESTing Astrocytes.

Author information

1
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
2
Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: yadong.huang@gladstone.ucsf.edu.

Abstract

Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity.

PMID:
26140600
DOI:
10.1016/j.stem.2015.06.011
[Indexed for MEDLINE]
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