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Genome Announc. 2015 Jul 2;3(4). pii: e00758-15. doi: 10.1128/genomeA.00758-15.

Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459.

Author information

1
Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia.
2
Microbiology Department, Central Tuberculosis Research Institute RAMS, Moscow, Russia.
3
W. Harry Feinstone Department of Molecular Microbiology & Immunology, Department of Molecular Microbiology & Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
4
Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Moscow, Russia valerid@vigg.ru.

Abstract

We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed unique mutations, which may elucidate new mechanisms of PZA resistance.

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