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Genet Res (Camb). 2015 Jul 3;97:e14. doi: 10.1017/S0016672315000142.

The role of GRIK4 gene in treatment-resistant depression.

Author information

1
Department of Cell and Developmental Biology,Sackler Faculty of Medicine,Tel Aviv University,Tel Aviv 69978,Israel.
2
Genetic Unit,IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli,Brescia,Italy.
3
Department of Molecular and Translational Medicine,University of Brescia,Brescia,Italy.
4
Psychiatric Hospital "Villa Santa Chiara",Verona,Italy.

Abstract

Several lines of evidence implicate abnormalities in glutamatergic neural transmission in major depressive disorder (MDD) and treatment response. A high percentage of MDD patients do not respond adequately to antidepressants and are classified as having treatment-resistant depression (TRD). In this study we investigated five GRIK4 variants, previously associated with antidepressants response, in an Italian cohort of 247 MDD no-TRD and 380 TRD patients. We found an association between rs11218030 G allele and TRD. Moreover, significant associations between rs11218030 and rs1954787 and the presence of psychotic symptoms were observed. In conclusion, our data support the involvement of GRIK4 in TRD and in the risk of developing psychotic symptoms during depressive episodes.

PMID:
26139080
DOI:
10.1017/S0016672315000142
[Indexed for MEDLINE]

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