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Cell Res. 2015 Jul;25(7):765-6. doi: 10.1038/cr.2015.62. Epub 2015 May 26.

Promoting metastasis: neutrophils and T cells join forces.

Author information

1
Institute of Pulmonary Medicine, Hadassah-Hebrew University Medical Center, 91120 Jerusalem, Israel.
2
Thoracic Oncology Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA.
3
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120 Jerusalem, Israel.

Abstract

The role neutrophils play in cancer is a matter of debate as both pro- and anti-tumor functions have been documented. In a recent publication in Nature, Coffelt et al. identify a new mechanism where neutrophils and T cells cooperate to generate metastasis-supporting immune suppression.

PMID:
26138787
PMCID:
PMC4493274
DOI:
10.1038/cr.2015.62
[Indexed for MEDLINE]
Free PMC Article

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