Format

Send to

Choose Destination
Arch Gynecol Obstet. 2016 Jan;293(1):5-10. doi: 10.1007/s00404-015-3809-8. Epub 2015 Jul 3.

Association of endometriosis and breast cancer: mini review of the literature.

Author information

1
Second Department of Obstetrics and Gynecology, University of Athens Aretaieion Hospital, Vas. Sofias Avenue 76, 11528, Athens, Greece. f.anifantaki@gmail.com.
2
Second Department of Obstetrics and Gynecology, University of Athens Aretaieion Hospital, Vas. Sofias Avenue 76, 11528, Athens, Greece.

Abstract

BACKGROUND:

Endometriosis is a common, estrogen-dependent, gynecological disease, which is defined as the presence of endometrial tissue outside the uterine cavity. Current data have associated endometriosis with specific malignancies, including ovarian and breast cancer.

PURPOSE:

The purpose of our study is to summarize and present published literature providing evidence regarding the possible relationship between endometriosis and breast cancer.

METHODS:

Pubmed and Scopus databases were searched systematically for studies that sought to identify a potential association of endometriosis and breast cancer. 15 relevant articles were retrieved and included in the present review.

RESULTS:

A small number of observational studies have shown a correlation of endometriosis and breast cancer. Other studies found that the risk of breast cancer increases with age. The scenario of an early interruption of the inflammatory process, derived from endometriosis, by oophorectomy and a possible consequent decrease in the risk of breast cancer has also been proposed. The hypothesis that both conditions could be related through common mutations on BRAC1 and BRAC2 genes has also been investigated.

CONCLUSION:

The available published evidence is inconclusive. Further studies are needed to evaluate the association of endometriosis and breast cancer and the possible pathogenetic pathways that relate the two disorders.

KEYWORDS:

Breast cancer; Breast malignancies; Breast neoplasm; Endometriosis

PMID:
26138306
DOI:
10.1007/s00404-015-3809-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center