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Biomed Opt Express. 2015 Apr 2;6(5):1534-52. doi: 10.1364/BOE.6.001534. eCollection 2015 May 1.

Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle.

Author information

1
Institut für Biomedizinische Optik, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany ; Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 Munich, Germany.
2
Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 Munich, Germany ; Optores GmbH, Nymphenburger Str. 10, 80335 München, Germany.
3
Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München, Oettingenstr. 67, 80538 Munich, Germany.
4
Augenklinik der Ludwig-Maximilians-Universität München, Mathildenstraße 8, 80336 Munich, Germany.

Abstract

We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal fall-off which we observe towards larger imaging angles. It is present in our 85° and 100° single volume images, but not in the mosaic. Our results suggest that 100° FOV OCT is possible with current swept source OCT technology.

KEYWORDS:

(120.3890) Medical optics instrumentation; (140.3510) Lasers, fiber; (170.3880) Medical and biological imaging; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography

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