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Exp Ther Med. 2015 May;9(5):1593-1596. Epub 2015 Feb 17.

Protective effect of probiotics in the treatment of infantile eczema.

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Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266071, P.R. China.
Department of Pediatrics, The Maternal-Child Healthcare Center of Qingdao, Qingdao, Shandong 266035, P.R. China.
Department of Pediatrics, Shandong Traffic hospital, Jinan, Shandong 250031, P.R. China.


The aim of the present study was to provide evidence for the application of probiotics in the prevention and treatment of infantile eczema by exploring changes in the intestinal Bifidobacteria levels and the Scoring Atopic Dermatitis (SCORAD) index prior and subsequent to treatment with probiotics in infants with eczema. A total of 40 infants with eczema were randomly divided into treatment and control groups. Prior and subsequent to the treatment, the SCORAD index was evaluated and the content of Bifidobacterium bifidum in the stool of each infant in the two groups was quantified using 16S rRNA/DNA quantitative polymerase chain reaction analysis. After four weeks of treatment with B. bifidum triple viable capsules, the levels of B. bifidum increased sharply (P<0.05) and the SCORAD index was notably reduced (P<0.05) as compared with the values prior to treatment. By contrast, neither the content of B. bifidum nor the SCORAD index changed significantly in the control group after four weeks (P>0.05). Following treatment, the levels of B. bifidum in the stools of the treatment group were significantly higher than those in the stools of the control group (P<0.05), and the SCORAD index was significantly lower than that of the control group (P<0.05). In conclusion, probiotic supplementation has a positive effect on the prevention and treatment of infantile eczema.


Bacillus bifidus; eczema; infants; probiotics

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