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J Virol. 2015 Sep;89(18):9689-92. doi: 10.1128/JVI.00708-15. Epub 2015 Jul 1.

Evolution of Influenza B Virus in Kuala Lumpur, Malaysia, between 1995 and 2008.

Author information

1
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg.
2
Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore.
3
Department of Medical Microbiology, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia.
4
Tropical Infectious Diseases Research and Education Centre, University Malaya, Kuala Lumpur, Malaysia.
5
J. Craig Venter Institute, Rockville, Maryland, USA.
6
Department of Biology, Center for Genomics & Systems Biology, and Global Institute of Public Health, New York University, New York, New York, USA.
7
Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
8
Duke Global Health Institute, Duke University, Durham, North Carolina, USA.
9
Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore Duke Global Health Institute, Duke University, Durham, North Carolina, USA jicsam@ummc.edu.my gavin.smith@duke-nus.edu.sg.

Abstract

Influenza B virus causes significant disease but remains understudied in tropical regions. We sequenced 72 influenza B viruses collected in Kuala Lumpur, Malaysia, from 1995 to 2008. The predominant circulating lineage (Victoria or Yamagata) changed every 1 to 3 years, and these shifts were associated with increased incidence of influenza B. We also found poor lineage matches with recommended influenza virus vaccine strains. While most influenza B virus lineages in Malaysia were short-lived, one circulated for 3 to 4 years.

PMID:
26136576
PMCID:
PMC4542393
DOI:
10.1128/JVI.00708-15
[Indexed for MEDLINE]
Free PMC Article

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