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Physiology (Bethesda). 2015 Jul;30(4):304-16. doi: 10.1152/physiol.00007.2015.

Humans In Hypoxia: A Conspiracy Of Maladaptation?!

Author information

1
John Rankin Laboratory of Pulmonary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and jdempsey@wisc.edu.
2
John Rankin Laboratory of Pulmonary Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; Department of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Abstract

We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia discussed include short-term and life-long residence at high altitudes, the intermittent hypoxemia attending sleep apnea, or training regimens prescribed for endurance athletes. We propose that hypoxia presents an insult to O2 transport, which is poorly tolerated in most humans because of the physiological cost.

PMID:
26136544
PMCID:
PMC4491526
DOI:
10.1152/physiol.00007.2015
[Indexed for MEDLINE]
Free PMC Article

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