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Fitoterapia. 2015 Sep;105:160-4. doi: 10.1016/j.fitote.2015.06.019. Epub 2015 Jun 30.

Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone.

Author information

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of botany, Chinese Academy of Science, Kunming 650201, People's Republic of China; University of Chinese Academy of Science, Beijing 100049, People's Republic of China.
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of botany, Chinese Academy of Science, Kunming 650201, People's Republic of China. Electronic address: liuyaping@mail.kib.ac.cn.
3
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming institute of botany, Chinese Academy of Science, Kunming 650201, People's Republic of China. Electronic address: xdluo@mail.kib.ac.cn.

Abstract

Three new monoterpenoid indole alkaloids, named normavacurine-21-one (1), 5-hydroxy-19, 20-E-alschomine (2), and 5-hydroxy-19, 20-Z-alschomine (3), together with thirteen known indole alkaloids (4-16) were isolated from the leaves of Alstonia scholaris cultivated in Kunming. Their structures were elucidated on the basis of extensive spectroscopic analysis, as well as by comparison with the reported spectroscopic data. The leaves of A. scholaris cultivated in Kunming, contained picrinine-type alkaloids, scholaricin-type alkaloids and nareline as major alkaloids. New compounds 1-3 might be derived from a common biogenetic precursor (5). Compounds 1, 5 and 10 exhibited significant antibacterial activity against Enterococcus faecalis, and 3, 9 and 14 against Pseudomonas aeruginosa with an MIC value of 0.781 μg/mL, while 14 showed moderate activity against Klepsiella pneumonia with an MIC value of 1.56 μg/mL.

KEYWORDS:

Alstonia scholaris; Antibacterial activity; Apocynaceae; Monoterpenoid indole alkaloids

PMID:
26136061
DOI:
10.1016/j.fitote.2015.06.019
[Indexed for MEDLINE]

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