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BMJ Case Rep. 2015 Jul 1;2015. pii: bcr2014208745. doi: 10.1136/bcr-2014-208745.

Rheumatoid meningitis: a rare complication of rheumatoid arthritis.

Author information

1
School of Medicine, Imperial College London, London, Greater London, UK William Harvey Hospital, Ashford, Kent, UK.
2
Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA.
3
Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA.

Abstract

We present a case of a 60-year-old Caucasian woman with a 23-year history of rheumatoid arthritis, who presented with a 2-week history of headache and cognitive/behavioural changes. On the basis of clinical features, radiology, laboratory data and meningeal biopsy, a diagnosis of rheumatoid meningitis was performed. High-dose intravenous methylprednisolone was used as initial treatment followed by oral prednisone. The patient's symptoms improved and repeat MRI scans confirmed resolution of the meningeal lesions. The clinical diagnosis of rheumatoid meningitis is difficult, but it must be considered in patients with long-standing rheumatoid arthritis presenting with neurological symptoms. Glucocorticoids or other immunomodulatory therapy are the mainstay of treatment.

PMID:
26135486
PMCID:
PMC4493174
DOI:
10.1136/bcr-2014-208745
[Indexed for MEDLINE]
Free PMC Article

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