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Am J Clin Nutr. 2015 Aug;102(2):368-75. doi: 10.3945/ajcn.114.101188. Epub 2015 Jul 1.

Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial.

Author information

1
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; cbondonno@meddent.uwa.edu.au.
2
School of Medicine and Pharmacology, University of Western Australia, Perth, Australia;
3
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden; and.
4
Research Centers, School of Medicine, Flinders University, Adelaide, Australia.

Abstract

BACKGROUND:

Dietary nitrate, which is in green leafy vegetables and beetroot, decreases blood pressure through the enterosalivary nitrate-nitrite-nitric oxide pathway in healthy individuals. Whether similar effects would occur in individuals with treated hypertension and, therefore, at increased risk of cardiovascular disease is unclear.

OBJECTIVE:

We assessed whether increased dietary nitrate intake by using beetroot juice for 1 wk lowers blood pressure in treated hypertensive men and women.

DESIGN:

Participants (n = 27) were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effect of 1-wk intake of nitrate-rich beetroot juice was compared with 1-wk intake of nitrate-depleted beetroot juice (placebo). The primary outcome was blood pressure assessed by measuring home blood pressure during the intervention and 24-h ambulatory blood pressure on day 7 of the intervention. Other outcomes included nitrate metabolism assessed by measuring nitrate and nitrite in plasma, saliva, and urine.

RESULTS:

Relative to the placebo, 1-wk intake of nitrate-rich beetroot juice resulted in a 3-fold increase in plasma nitrite and nitrate, a 7-fold increase in salivary nitrite, an 8-fold higher salivary nitrate, and a 4-fold increase in both urinary nitrite and nitrate (P < 0.001). However, no differences in home blood pressure and 24-h ambulatory blood pressure were observed with 1-wk intake of nitrate-rich beetroot juice in comparison with the placebo.

CONCLUSION:

An increase in dietary nitrate intake may not be an effective short-term approach to further lower blood pressure in treated hypertensive subjects.

KEYWORDS:

beetroot; blood pressure; hypertension; nitrate; nitric oxide

PMID:
26135348
DOI:
10.3945/ajcn.114.101188
[Indexed for MEDLINE]

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