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Cell Microbiol. 2015 Sep;17(9):1277-85. doi: 10.1111/cmi.12480. Epub 2015 Jul 28.

The innate immune response in human tuberculosis.

Author information

1
Mill Hill Laboratory, The Francis Crick Institute, London, UK.

Abstract

Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune system before the initiation of an adaptive immune response. This innate protection requires a variety of robust cell autonomous responses from many different host immune cell types. However, Mtb has evolved strategies to circumvent some of these defences. In this mini-review, we discuss these host-pathogen interactions with a focus on studies performed in human cells and/or supported by human genetics studies (such as genome-wide association studies).

PMID:
26135005
PMCID:
PMC4832344
DOI:
10.1111/cmi.12480
[Indexed for MEDLINE]
Free PMC Article

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