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Cold Spring Harb Perspect Biol. 2015 Jul 1;7(7):a015784. doi: 10.1101/cshperspect.a015784.

Emergent Properties of the Metaphase Spindle.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany Integrative Research Institute (IRI) for the Life Sciences, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.
2
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

Abstract

A metaphase spindle is a complex structure consisting of microtubules and a myriad of different proteins that modulate microtubule dynamics together with chromatin and kinetochores. A decade ago, a full description of spindle formation and function seemed a lofty goal. Here, we describe how work in the last 10 years combining cataloging of spindle components, the characterization of their biochemical activities using single-molecule techniques, and theory have advanced our knowledge. Taken together, these advances suggest that a full understanding of spindle assembly and function may soon be possible.

PMID:
26134313
PMCID:
PMC4484974
DOI:
10.1101/cshperspect.a015784
[Indexed for MEDLINE]
Free PMC Article

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