Format

Send to

Choose Destination
Biochim Biophys Acta. 2015 Aug;1849(8):1051-6. doi: 10.1016/j.bbagrm.2015.06.012. Epub 2015 Jun 28.

Perspective on unraveling the versatility of 'co-repressor' complexes.

Author information

1
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands.
2
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands. Electronic address: M.vermeulen@ncmls.ru.nl.

Abstract

A multitude of post-translational modifications take place on histones, one of the best studied being acetylation on lysine residues, which is generally associated with gene activation. During the last decades, several so-called co-repressor protein complexes that carry out the reverse process, histone deacetylation, have been identified and characterized, such as the Sin3, N-CoR/SMRT and NuRD complexes. Although a repressive role for these complexes in regulating gene expression is well established, accumulating evidence also points to a role in gene activation. Here, we argue that integration of various state-of-the-art technologies, addressing different aspects of transcriptional regulation, is essential to unravel this apparent biological versatility of 'co-repressor' complexes.

KEYWORDS:

Co-repressor complexes; Gene regulation; Histone deacetylation; Technology integration

PMID:
26130598
DOI:
10.1016/j.bbagrm.2015.06.012
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center