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Genet Mol Res. 2015 May 18;14(2):5221-8. doi: 10.4238/2015.May.18.13.

Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania.

Author information

1
Faculty of Technical Medical Sciences, Medical University of Tirana, Tirana, Albania.
2
MAGI Non-Profit Human Medical Genetics Institute, Rovereto, Italy paolo.maltese@assomagi.org.
3
Faculty of Natural Sciences, University of Tirana, Tirana, Albania.
4
Faculty of Medicine, Catholic University "Our Lady of Good Counsel", Tirana, Albania.
5
National Blood Transfusion Center, Tirana, Albania.
6
MAGI Non-Profit Human Medical Genetics Institute, Rovereto, Italy.

Abstract

Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are correlated with different disease course, severity, and response to therapy. We isolated DNA from 75 HBV-positive blood donors, chosen randomly from the database of the National Blood Bank in Tirana, to specifically analyze the UGT1A1 polymorphism to determine its correlations with bilirubin levels and liver function. The large number of subjects who were HBV-positive carriers of heterozygosis or homozygosis for the UGT1A1*28 (TA)7 polymorphism suggests that these individuals may be more susceptible to cancer and should follow a strict regime of prevention.

PMID:
26125716
DOI:
10.4238/2015.May.18.13
[Indexed for MEDLINE]
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