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Eur J Clin Pharmacol. 1989;37(3):267-72.

The pharmacokinetics of midazolam in paediatric patients.

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Department of Anaesthesia, Medical School, University of Stellenbosch, South Africa.


A serum concentration profile study on midazolam in children was done. Fifty six children aged 3-10 years took part. The routes investigated were intravenous, intramuscular, rectal and oral at 0.15, and the oral at 0.45 and 1 Serum concentration levels for 5 h were studied using gas liquid chromatography. The volume of distribution, Vss, was 1.29, the elimination half-life 1.17 h and the serum clearance 9.11 Peak serum concentrations for the intramuscular, rectal and oral routes were at 15 min, 30 min and 53 min respectively. Bioavailability was 87%, 18%, 27% respectively at a dose of 0.15 The oral route bioavailability halved to 15% at the two higher doses. Bioequivalence was present between the 0.15 intramuscular dose and the 0.45 oral dose from 45 to 120 min.

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