Format

Send to

Choose Destination
Eur J Pediatr. 1989 Dec;149(3):162-3.

Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia during L-asparaginase therapy.

Author information

1
Department of Paediatrics, University of Tsukuba, Ibaraki, Japan.

Abstract

We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis during L-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins. L-asparaginase induced coagulopathy may cause osteonecrosis.

PMID:
2612502
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center