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Afr Health Sci. 2015 Jun;15(2):368-77. doi: 10.4314/ahs.v15i2.9.

Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State.

Author information

1
Department of Medical Microbiology, Immunology and Parasitology, College of Medicine and Health Sciences, Bahir Dar University, Ethiopia.
2
Department of Regional Mycobacteriology Laboratory, Bahir Dar Regional Health Research Laboratory Center, Bahir Dar, Ethiopia.

Abstract

BACKGROUND:

Multidrug resistant tuberculosis(MDR-TB) is becoming a major threat to tuberculosis control programs in Ethiopia.

OBJECTIVES:

To determine risk factors of MDR-TB patients in Amhara National Regional State, Ethiopia.

METHODS:

Case-control study was conducted from May 2013 to January 2014. Resistance to rifampicin and isoniazid were done molecularly using line probe assay. TB patients infected with MDR-M.tuberculosis and non MDR-M.tuberculosis strain were considered as cases and controls, respectively. Data was collected using structured questionnaire with face to face interview. Patients' clinical record review was also done.Multivariate analysis was computed to determine the risk factors of MDR-TB.

RESULTS:

A total of 153 MDR-TB and equal number of non MDR-TB patients' participated in the study. Patients who had TB treatment failure (AOR=13.5,CI=2.69-70), cavitations on chest x-ray (AOR=1.9,CI=1.1-3.38) and contact with MDR-TB patients (AOR=1.4,CI=0.19-0.39) were more likely to be MDR-TB patients. Low monthly income (AOR=1.1,CI=0.34-0.47),alcohol consumption (AOR=1.5,CI=0.2-0.98) and young age (AOR=2.9,CI=1.07-7.68) were the other risk factors of MDR-TB.

CONCLUSIONS:

TB treatment failure, cavitation on chest X-ray, contact with MDR-TB patients and low socioeconomic status were important risk factors for development of MDR-TB. Therefore, strict adherence to directly observed therapy, appropriate management of TB patients and advice on the value of nutrients are helpful to control the spreading of MDR-TB.

KEYWORDS:

Ethiopia; MDR-TB; Risk factors

PMID:
26124781
PMCID:
PMC4480497
DOI:
10.4314/ahs.v15i2.9
[Indexed for MEDLINE]
Free PMC Article

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