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Front Microbiol. 2015 Jun 12;6:572. doi: 10.3389/fmicb.2015.00572. eCollection 2015.

The membrane: transertion as an organizing principle in membrane heterogeneity.

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Department of Biochemistry and Molecular Biology, Graduate School of Science and Engineering, Saitama University, Saitama Japan.
Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva Israel.
Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston Houston, TX, USA.
Laboratory of Microbiology Signals and Microenvironment EA 4312, Department of Science, University of Rouen, Mont-Saint-Aignan France.


The bacterial membrane exhibits a significantly heterogeneous distribution of lipids and proteins. This heterogeneity results mainly from lipid-lipid, protein-protein, and lipid-protein associations which are orchestrated by the coupled transcription, translation and insertion of nascent proteins into and through membrane (transertion). Transertion is central not only to the individual assembly and disassembly of large physically linked groups of macromolecules (alias hyperstructures) but also to the interactions between these hyperstructures. We review here these interactions in the context of the processes in Bacillus subtilis and Escherichia coli of nutrient sensing, membrane synthesis, cytoskeletal dynamics, DNA replication, chromosome segregation, and cell division.


Bacillus subtilis; Escherichia coli; hyperstructures; lipid domain; membrane; transertion

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