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Mol Cancer. 2015 Jun 30;14:125. doi: 10.1186/s12943-015-0402-5.

Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer.

Author information

1
Department of Pathology, Harbin Medical University, Harbin, China. wtzpath@163.com.
2
Department of Gastrointestinal Medical Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China. wangguangyu03@163.com.
3
Faculty of Health Sciences, University of Macau, Taipa, Macau, China. yb47615@umac.mo.
4
Center of Cardiovascular, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, China. 13836117714@163.com.
5
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. wangdong@ems.hrbmu.edu.cn.
6
Department of Gastrointestinal Surgery, International Hospital of Pecking University, Beijing, China. ningning301@126.com.
7
Department of Pathology, Harbin Medical University, Harbin, China. lixiaobo@ems.hrbmu.edu.cn.

Abstract

RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of human malignancies. Let-7, one of the most well-known tumor suppressors, is frequently down-regulated in a variety of human cancers. The RBP LIN28A/LIN28B, a direct target of the let-7 family of miRNAs, is an inhibitor of let-7 biogenesis and is frequently up-regulated in cancers. Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors is reportedly involved in cancer development, contributing to cellular proliferation, cell death resistance, angiogenesis, metastasis, metabolism reprogramming, tumor-associated inflammation, genome instability, acquiring immortality and evading immune destruction. In this review, we summarized the mechanisms of LIN28A/LIN28B and let-7 loop aberrant regulation in human cancer and discussed the roles and potential mechanisms of the LIN28A/LIN28B and let-7 loop in regulating the hallmarks of cancer. The crosstalk between LIN28A/LIN28B and let-7 loop and certain oncogenes (such as MYC, RAS, PI3K/AKT, NF-κB and β-catenin) in regulating hallmarks of cancer has also been discussed.

PMID:
26123544
PMCID:
PMC4512107
DOI:
10.1186/s12943-015-0402-5
[Indexed for MEDLINE]
Free PMC Article

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