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Mol Imaging Biol. 2016 Feb;18(1):99-108. doi: 10.1007/s11307-015-0873-1.

Comparison of Somatostatin Receptor 2-Targeting PET Tracers in the Detection of Mouse Atherosclerotic Plaques.

Author information

1
Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland.
2
Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland.
3
Turku Center for Disease Modeling, University of Turku, Turku, Finland.
4
Department of Surgery, University of Turku, Turku, Finland.
5
Department of Pathology, Turku University Hospital and University of Turku, Turku, Finland.
6
Heart Center, Turku University Hospital and University of Turku, Turku, Finland.
7
Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, FI-20520, Turku, Finland. anne.roivainen@utu.fi.
8
Turku Center for Disease Modeling, University of Turku, Turku, Finland. anne.roivainen@utu.fi.

Abstract

PURPOSE:

Rupture-prone atherosclerotic plaques are characterized by accumulation of macrophages, which have shown to express somatostatin type 2 receptors. We aimed to investigate whether somatostatin receptor-targeting positron emission tomography (PET) tracers, [(68)Ga]DOTANOC, [(18)F]FDR-NOC, and [(68)Ga]DOTATATE, can detect inflamed atherosclerotic plaques.

PROCEDURES:

Atherosclerotic IGF-II/LDLR(-/-)ApoB(100/100) mice were studied in vivo and ex vivo for tracer uptake into atherosclerotic plaques. Furthermore, [(68)Ga]DOTANOC and [(68)Ga]DOTATATE were compared in a head-to-head setting for in vivo PET/X-ray computed tomography (CT) imaging characteristics.

RESULTS:

Ex vivo uptake of [(68)Ga]DOTANOC and [(68)Ga]DOTATATE in the aorta was higher in atherosclerotic mice compared to control C57Bl/6N mice, while the aortic uptake of [(18)F]FDR-NOC showed no genotype difference. Unlike [(18)F]FDR-NOC, [(68)Ga]DOTANOC and [(68)Ga]DOTATATE showed preferential binding to atherosclerotic plaques with plaque-to-wall ratio of 1.7 ± 0.3 and 2.1 ± 0.5, respectively. However, the aortic uptake and aorta-to-blood ratio of [(68)Ga]DOTANOC were higher compared to [(68)Ga]DOTATATE in in vivo PET/CT imaging.

CONCLUSION:

Our results demonstrate superior applicability for [(68)Ga]DOTANOC and [(68)Ga]DOTATATE in the detection of atherosclerotic plaques compared to [(18)F]FDR-NOC.

KEYWORDS:

Atherosclerosis; Autoradiography; Biodistribution; Positron emission tomography; Somatostatin receptor

PMID:
26122428
DOI:
10.1007/s11307-015-0873-1
[Indexed for MEDLINE]

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