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Lifetime Data Anal. 2016 Jul;22(3):343-62. doi: 10.1007/s10985-015-9334-z. Epub 2015 Jun 30.

Regression analysis of longitudinal data with correlated censoring and observation times.

Author information

1
Department of Mathematics and Statistics, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA. Y.Li@uncc.edu.
2
Department of Epidemiology & Biostatistics, University of Maryland, College Park, MD, 20742, USA.
3
Department of Mathematics and Statistics, University of New Hampshire, Durham, NH, 03824, USA.
4
Department of Statistics, University of Missouri, Columbia, MO, 65211, USA.

Abstract

Longitudinal data occur in many fields such as the medical follow-up studies that involve repeated measurements. For their analysis, most existing approaches assume that the observation or follow-up times are independent of the response process either completely or given some covariates. In practice, it is apparent that this may not be true. In this paper, we present a joint analysis approach that allows the possible mutual correlations that can be characterized by time-dependent random effects. Estimating equations are developed for the parameter estimation and the resulted estimators are shown to be consistent and asymptotically normal. The finite sample performance of the proposed estimators is assessed through a simulation study and an illustrative example from a skin cancer study is provided.

KEYWORDS:

Estimating equation; Informative censoring; Informative observation process; Longitudinal data

PMID:
26122093
DOI:
10.1007/s10985-015-9334-z
[Indexed for MEDLINE]

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