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PLoS One. 2015 Jun 29;10(6):e0131820. doi: 10.1371/journal.pone.0131820. eCollection 2015.

Association of Oxytocin Receptor Gene (OXTR) rs53576 Polymorphism with Sociality: A Meta-Analysis.

Author information

1
College of Education, Dali University, Dali, China.
2
College of Sociology and Psychology, Southwest University for Nationalities, Chengdu, China.
3
Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, Florida, United States of America; Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China.
4
Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, United States of America.
5
Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China.

Abstract

A common variant in the oxytocin receptor gene (OXTR), rs53576, has been broadly linked to socially related personality traits and behaviors. However, the pattern of published results is inconsistent. Here, we performed a meta-analysis to comprehensively evaluate the association. The literature was searched for relevant studies and effect sizes between individuals homozygous for the G allele (GG) and individuals with A allele carriers (AA/AG). Specifically, two indices of sociality were evaluated independently: i) general sociality (24 samples, n = 4955), i.e., how an individual responds to other people in general; and ii) close relationships (15 samples, n = 5262), i.e., how an individual responds to individuals with closed connections (parent-child or romantic relationship). We found positive association between the rs53576 polymorphism and general sociality (Cohen's d = 0.11, p = .02); G allele homozygotes had higher general sociality than the A allele carriers. However, the meta-analyses did not detect significant genetic association between rs53576 and close relationships (Cohen's d = 0.01, p = .64). In conclusion, genetic variation in the rs53576 influences general sociality, which further implies that it is worthy to systematically examine whether the rs53576 is a valid genetic marker for socially related psychiatric disorders.

PMID:
26121678
PMCID:
PMC4488068
DOI:
10.1371/journal.pone.0131820
[Indexed for MEDLINE]
Free PMC Article

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