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Nat Cell Biol. 2015 Aug;17(8):955-63. doi: 10.1038/ncb3191. Epub 2015 Jun 29.

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch.

Author information

1
Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Abstract

During cell migration, the forces generated in the actin cytoskeleton are transmitted across transmembrane receptors to the extracellular matrix or other cells through a series of mechanosensitive, regulable protein-protein interactions termed the molecular clutch. In integrin-based focal adhesions, the proteins forming this linkage are organized into a conserved three-dimensional nano-architecture. Here we discuss how the physical interactions between the actin cytoskeleton and focal-adhesion-associated molecules mediate force transmission from the molecular clutch to the extracellular matrix.

PMID:
26121555
PMCID:
PMC6300998
DOI:
10.1038/ncb3191
[Indexed for MEDLINE]
Free PMC Article

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