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Assay Drug Dev Technol. 2015 Jun;13(5):254-61. doi: 10.1089/adt.2015.29001.rtd. Epub 2015 Jun 29.

Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

Author information

1
1 Senior Advisor to the Director, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland.
2
2 Vice President and General Manager, Corning Life Sciences , Tewksbury, Massachusetts.
3
3 Chemist, Molecular Toxicology and Informatics Group, Biomolecular Screening, National Institute of Environmental Science, National Institutes of Health , Research Triangle Park, North Carolina.
4
4 Director of Research, Anesthesia and Pain Medicine/Staff Anesthesiologist, Hospital for Sick Children, University of Toronto , Toronto, Ontario, Canada .
5
5 Director, National Center for Environmental Assessment , Environmental Protection Agency, Arlington, Virginia.
6
6 CEO , 3D Biomatrix, Ann Arbor, Michigan.
7
7 Research Fellow, Avery Group, Eskitis Institute for Drug Discovery, Griffith University , Nathan, Queensland, Australia .
8
8 Leader, Biomolecular Screening and Probe Development, Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland.
PMID:
26120951
PMCID:
PMC4507360
DOI:
10.1089/adt.2015.29001.rtd
[Indexed for MEDLINE]
Free PMC Article

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