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J Diabetes. 2016 Jul;8(4):516-32. doi: 10.1111/1753-0407.12325. Epub 2015 Sep 1.

Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis.

Author information

1
Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA.
2
Department of Epidemiology, School of Public Health, Providence, Rhode Island, USA.
3
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
4
Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA.
5
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
6
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
7
Department of Medicine, Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Abstract

BACKGROUND:

Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits.

METHODS:

MEDLINE was searched for cross-sectional and prospective studies published before 8 March 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures.

RESULTS:

Forty-one cross-sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95% confidence interval [CI] 1.44-2.54) for dioxins, 2.39 (95% CI 1.86-3.08) for total PCBs, and 2.30 (95% CI 1.81-2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95% CI 1.13-1.87) for BPA and 1.48 (95% CI 0.98-2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance.

CONCLUSIONS:

Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.

KEYWORDS:

bisphenol A; diabetes; endocrine-disrupting chemical; meta-analysis; meta分析; phthalate; 内分泌干扰物; 双酚A; 糖尿病; 邻苯二甲酸盐

PMID:
26119400
DOI:
10.1111/1753-0407.12325
[Indexed for MEDLINE]

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